Fri Jul 26 2024

33 articles - From Friday Jul 19 2024 to Friday Jul 26 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Inflamm Bowel Dis

Invasive Therapeutic Strategies for Stricturing Crohn's Disease in Childhood: A Systematic Review and Meta-Analysis.

Surgical resection is the best option for treating strictures in pediatric CD patients in terms of recurrence rate, compared with endoscopic balloon dilation and strictureplasty. Nevertheless, surgical resection is associated with more adverse events.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Dietary patterns in the progression of metabolic dysfunction-associated fatty liver disease to advanced liver disease: a prospective cohort study.

These findings highlight the detrimental effects of MAFLD on the development of subsequent liver diseases and the importance of dietary patterns in managing MAFLD.

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Fish oil supplementation modifies the associations between genetically predicted and observed levels of blood lipids: a cross-sectional gene-diet interaction study in UK Biobank.

Fish oil supplementation attenuates the association between genetically predicted and observed circulating levels of total cholesterol, LDL cholesterol, and triglycerides, while accentuating the corresponding association for HDL cholesterol in individuals of European ancestry. Further research is needed to understand the clinical implications of these findings.

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Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.

Folate intake was not differentially associated with CRC risk according to mutations in the genes explored. The nominally significant differential mutation effects observed in a few genes warrants further investigation.

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Plant-based diet in hyperkalemic chronic kidney disease patients receiving sodium zirconium cyclosilicate: A feasibility clinical trial.

PBD in hyperkalemia-prone CKD patients receiving SZC improved dietary quality and increased the intake of healthy foods while plasma potassium concentration remained stable within normal values for most patients. Clinical Trial Registry number NCT04207203 (

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Quercetin intervention reduced hepatic fat deposition in patients with nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled crossover clinical trial.

Twelve weeks treatment of quercetin could reduce intrahepatic lipid contents in patients with NAFLD, possibly explained by a slightly larger body weight loss in the quercetin group. The trial is registered at as ChiCTR2100047904. The trial is registered at as ChiCTR2100047904.

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Relationship between Very Early Enteral Nutrition and Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in cardiovascular surgery patients: A propensity score-matched study.

Among patients who underwent cardiovascular surgery, very early EN provided on the day after surgery was associated with a lower incidence of PICS and a shorter length of hospital stay than EN provided two or three days after surgery.

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Serum S-adenosylhomocysteine, rather than homocysteine, is associated with hepatocellular carcinoma survival: a prospective cohort study.

Higher serum SAH concentrations, rather than homocysteine, were independently associated with worse survival in HCC patients, regardless of the genetic variants of one-carbon metabolism key enzymes. These findings suggesting that SAH may serve as a novel metabolism-related prognostic biomarker for HCC.

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Vitamin D and Heart Failure Risk among Individuals with Type 2 Diabetes: Observational and Mendelian Randomization Studies.

s/interpretation Higher serum 25(OH)D was associated with lower HF risk among individuals with T2D and the MR analysis suggested a potential causal relationship. These findings indicate a role of maintaining adequate vitamin D status in the prevention of HF among individuals with T2D.

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Inflamm Bowel Dis

High Healthcare Costs in Childhood Inflammatory Bowel Disease: Development of a Prediction Model Using Linked Clinical and Health Administrative Data.

The cost of caring for children with IBD in the first year after diagnosis is immense and can be predicted based on characteristics at diagnosis. Efforts that mitigate rising costs without compromising quality of care are needed.

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Identification of the M2 Macrophage-associated Gene THBS2 as a Predictive Marker for Inflammatory Cancer Transformation.

To sum up, patients with UC exhibiting reduced M2 macrophage infiltration have a higher propensity for CAC development, making THBS2 a crucial focus for converting UC into CAC. Furthermore, identifying antibody analogues targeting THBS2 could potentially lower the likelihood of CAC transformation in patients with UC.

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Intestinal Ultrasound, Fecal Calprotectin, and Their Combination to Predict Endoscopic Mucosal Healing in Ulcerative Colitis: A Real-Life Cross-Sectional Study.

The combination of IUS and FC is effective in identifying mucosal healing in UC. Noninvasive evaluation of mucosal healing is possible for most UC patients.

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The Prevalence and Characteristics of Inflammatory Bowel Disease-related Ocular Involvement in Children.

The prevalence of ocular involvement in children with IBD is rare and steady; it is also associated with a greater usage of systemic corticosteroids and biologic agents, potentially representing a more severe disease course.

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J Crohns Colitis

Chronic poor sleep is associated with increased disease activity in patients with ulcerative colitis: Prospective observational study in Japan.

Concomitant chronic poor sleep may have a negative influence on the disease activity in patients with inflammatory bowel disease, especially in those with ulcerative colitis.

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Classifying Inflammation on Intestinal Ultrasound Images and Cineloops - A Learning Curve Study.

We found considerable individual and group-level differences in learning curves supporting the concept of competency-based training for assessing bowel wall thickness, color Doppler signal and inflammatory fat. However, despite practice over 80 cases, novices did not improve in their interpretation of bowel wall stratification, suggesting that a different approach is needed for this parameter.

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Preventable predictive factors of post-colonoscopy colorectal cancer in inflammatory bowel disease.

More than 50% of CRCs in our population were PCCRC. PCCRCs were associated with previous inadequate cleansing and occurred more frequently in high-risk patients.

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Re-evaluating Methods for Assessing Differences in Response in Ileal vs. Colonic Crohn's Disease: A Post-hoc Analysis of the FITZROY Trial.

Filgotinib demonstrated similar efficacy in ileal-dominant and isolated colonic CD when controlling for baseline disease activity and clustering effects.

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The Natural History of Crohn's Disease Leading to Intestinal Failure: A Longitudinal Cohort Study from 1973 to 2018.

Patients with Crohn's disease complicated by intestinal failure experienced a more persistently severe preceding course of Crohn's disease but were not more likely to be treated with biological therapy.

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The microRNA expression in crypt-top and crypt-bottom colonic epithelial cell populations demonstrates cell-type specificity and correlates with endoscopic activity in ulcerative colitis.

miRNA expression was specific to colonic epithelial cell populations and UC state, reflecting endoscopic disease activity. Irrespective of the UC state, deregulated epithelial miRNAs were associated with regulation of intestinal barrier integrity.

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Liver Transpl

Cystatin C and the difference between cystatin C and serum creatinine: Improved metrics to predict waitlist mortality among decompensated cirrhosis patients.

Our study demonstrates that not only is cysC more associated with waitlist mortality than sCr, but that cysCsCrdiff represents a novel independent metric associated with waitlist mortality.

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Normothermic regional perfusion in controlled DCD liver procurement: Outcomes of the Swedish national implementation protocol.

Study protocol MRCP in cDCD patients showed no signs of subclinical biliary strictures. Evaluation of the Swedish national pilot of cDCD liver transplantation with mandatory NRP shows comparable outcomes to a matched DBD cohort with 94.4 one-year patient and graft survival and no incidence of NAS within the first year.

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Pancreatology

Near total head resection of pancreas in patients with chronic pancreatitis - Outcome of a novel surgical technique.

BDPPHR is a novel and safe technique of near total head resection which results in very good pain relief in 81 % of patients.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

J Crohns Colitis

Rethinking Faecal Microbiota Transplant for Pouchitis.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Autologous Fat Grafting For Perianal Fistula in Behçet's Disease: A Case Report.

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Diagnostic and Therapeutic Challenges in Severe Peristomal Pyoderma Gangrenosum.

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Pouch Salvage of Long Rectal Cuff Syndrome: Excision of Retained Rectum and Mesorectum With Conversion to Ileoanal Anastomosis.

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Risankizumab Is Effective for The Management of Crohn's Disease of the Pouch.

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Successful Long-Term Treatment of Collagenous Sprue With Tacrolimus in a 25-Year-Old With Severe Intestinal Failure.

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Liver Transpl

CON: Satellite clinics are a marketing tool and do not improve access and equity in liver transplantation.

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How satellite clinics can improve access to liver transplantation.

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The liver frailty index enhances mortality risk prediction above and beyond MELD 3.0 alone.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

Cystic fibrosis transmembrane conductance regulator (CFTR) variants and CFTR function in patients with pancreatitis.

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Letter to the editor: Prevalence and risk factors of fatigue and its association with quality of life among patients with chronic pancreatitis: A cross-sectional study.

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